Mildronate dihydrate, also known as meldonium, has gained attention in the sports community due to its purported benefits in enhancing athletic performance and recovery. Originally developed as a pharmaceutical compound for the treatment of ischemic heart diseases, research has increasingly focused on its applications in sports.
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Mechanism of Action
Mildronate dihydrate works by inhibiting the enzyme carnitine acyltransferase, which plays a critical role in the metabolism of fatty acids. This action leads to:
- Increased anaerobic metabolism
- Improved endurance performance
- Enhanced recovery after exertion
Benefits in Sports
The potential advantages of Mildronate dihydrate in athletic performance include:
- Enhanced exercise tolerance
- Improved recovery rates
- Reduction in fatigue during prolonged physical activity
Scientific Research
Numerous studies have explored the pharmacological effects of Mildronate, showing promising results in various types of sports. However, the findings are still in the early stages, requiring further investigation to support widespread use.
Regulatory Status
It is important to note that Mildronate dihydrate was added to the World Anti-Doping Agency’s (WADA) prohibited list in 2016. Athletes should be aware of the legal implications of using this substance, as testing positive can lead to sanctions.
Conclusion
While Mildronate dihydrate has shown potential benefits for athletes, its status as a banned substance and the need for more extensive scientific research should be taken into consideration. Athletes looking for an edge in performance must weigh the risks and benefits before considering its use.

